Differential Gene Expression in Cell Types of the Human Skeletal Muscle: A Bioinformatics-Based Meta-Review

PURPOSE: This study evaluates the differences in expression of genes frequently analyzed field exercise science between skeletal muscle tissue and various cell types that comprise tissue.METHODS: We summarized proteins expressed were published “Exercise Science” journal from 2015 to present. Thereafter, we selected 15 most muscle. These horizontally compared for components cultured cells based on NCBI Gene Expression Omnibus DataSets.RESULTS: The (encoding proteins) tissues PPARGC1A, PPARD, MTOR, MAP1LC3A, MAP1LC3B, PRKAA1, AKT1, SLC2A4, MAPK1, COX4I1, MAPK14, MEF2A, MAPK8, RPS6KB1, SOD1. Among them, COX4I1 specifically However, other was found be significantly affected tissue.CONCLUSIONS: Genes such as which are muscle, may without pretreating (such perfusion) tissue. depend type. Thus, instances, pretreatment, perfusion isolation, should considered.